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KMID : 0363219920300040484
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Korean Journal of Dermatology
1992 Volume.30 No. 4 p.484 ~ p.491
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The Effects of PUVA on Epidermal Melanocytes in C57BL, Mice
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Abstract
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The object of this study is to evaluate the effects of repeated PUVA aplliccations on epidermal melanocytes. The changes in the number of melanocytes is compared to the frequency of PUVA applications.
26 adult male C57BL mice were used. About an hour after application of 0.1% solution of 8-methoxypsoralen, UVA was delivered two or four times a week on both ears of mice with blacklight fluorescent tube (Waldmann UV-800). Weekly examinations of
melanocytes were mede for 4 weeks on split epidermal sheets treated with DOPA solution.
@ES The results were as follows.
@EN 1. Repeated PUVA applications revealed a significant increase in the number of melanocytes. With PUVA, two times a week, the number of melanocytes was increased from 83.2±7.2/㎟ (unirradiated ear) to 250.6±34.7/㎟ after one week and
525.5±66.7/㎟
after 4 weeks.
With PUVA, four tims a week, the number of melanocytes was increased from 83.2±7.2/㎟ (unirradiated ear) to 437.0±74.0/㎟ after one week and 686.3±27.8/㎟ after 4 weeks.
2. PUVA. four times a week, elicited higher melanocyte density than PUVA. two times a week, under the same period of treatment.
3. After two weeks, the same amount of irradiation increased the number of melanocytes more in PUVA, four times a week than in PUVA, two times a week.
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